Appraisal the Protective Effects of Cymbopogon Schoenanthus Extract against Reproductive Disorders and Carcinogenic Effects of Formalin in Experimental Male Rats

Document Type : Original Research Paper


1 Food Toxicology and Contaminants Departmetn, National Research Centre, PostCode 12622, Dokki, Giza, Egypt

2 Nutrition and Food Science Departmet, National Research Centre, PostCode 12622, Dokki, Giza, Egypt

3 Molecular Biology Department, National Research Centre, PostCode 12622, Dokki, Giza, Egypt

4 Pathology Department, Faculty of Veterinary Medicine, Post Code 12211, Cairo University, Giza, Egypt


Formaldehyde has been documented to be naturally present in many common foods. There has been a big public concern over the use of formaldehyde in the preservation of food. Also, it is commonly used as a chemical substance, usually in the life and can interact with many bio-substance in the human body. The present study target to investigate the protective effects of  Cymbopogon schoenanthus (CS) extract against the reproductive and carcinogenic effects of formaldehyde on male rats. The Albino male rats were divided into equal six groups, first group: rendered as a control group; second group: received formalin (100 mg/kg bw) and third group and forth group: were received SC extract at (50 and 100 mg) respectively; fifth group and sixth group were received formalin (100mg /kg bw) + SC extract (50mg) and formalin (100mg /kg bw)+ SC extract (100 mg) respectively. At the end of the experiment the animals were scarified and blood samples were collected for measurement all tested parameters. The results showed that the oral exposure to formaldehyde at a dose of 100 mg/kg bw resulted in significant negative effects in all tested parameters, while the CS extract at tow doses (50 and 100 mg) alone or in combination with formalin restored the negative effects to normal levels compared with the untreated group. The histopathological examination was studied on testis tissues and the histopathological pictures showed the CS extract at tow mention doses had ameliorate the adverse effects that induced by formaldehyde hazards.